Joe Manganiello Reveals 7-Year Life-Threatening Health Battle and Life-Saving Organ Amputation in New Memoir Bloodlines

Highlights Joe Manganiello’s memoir reveals a secret 7-year autoimmune health battle with multiple near-death experiences. The True Blood star underwent a life-saving organ amputation and found no answers from traditional medicine. Manganiello turned to shamans, ancestry research, and spirituality to survive his devastating health crisis. Joe Manganiello was living what looked like the dream — a skyrocketing career, a high-profile marriage, and a reputation for having what many called the best physique in Hollywood. Then, without warning, it all started to fall apart from the inside. The True Blood and Magic Mike star is pulling back the curtain on a devastating, previously hidden health crisis in his upcoming memoir, Bloodlines , due out October 13 from Simon & Schuster . The book reveals for the first time the full scope of a life-threatening ordeal that consumed nearly a decade of his life. A cascade of autoimmune-related illnesses attacked his skin, thyroid, eyes, lungs, and digestive system, plunging him into a seven-year battle plagued by chronic pain, a life-saving organ amputation, existential crisis and a prolonged fight for survival that left doctors with few answers and no clear explanation. The memoir, which publisher Simon & Schuster is calling a “gripping” account, details a previously undisclosed health ordeal marked by multiple near-death experiences and medical crises that led him beyond medicine and into a remarkable, globe-spanning quest that revealed answers about his ancestry, inherited trauma, and the deeper histories we carry. BEVERLY HILLS, CALIFORNIA – MARCH 12: Joe Manganiello attends the 2023 Vanity Fair Oscar Party Hosted By Radhika Jones at Wallis Annenberg Center for the Performing Arts on March 12, 2023 in Beverly Hills, California. (Photo by Amy Sussman/Getty Images) Manganiello, now 49, has been candid in the lead-up to the book’s release, describing the years-long fight as the darkest stretch of his life. He told People it was the “most brutally difficult” time of his life and wouldn’t wish it on his worst enemy. The health issue was as baffling as it was relentless. Despite seeking treatment through conventional Western medicine, Manganiello could not get a clear diagnosis or a path forward. Doctors were stumped. Traditional medicine provided little clarity or solace, leaving him to seek answers elsewhere. What followed was an unconventional journey that took him far outside the walls of any hospital. The search led Manganiello to shamans, pagan rituals, ancient myths, long-lost family records, and the rebirth of his own spirituality. That spiritual reckoning ultimately collided with a deeper genealogical excavation. The search led him deep into his own bloodline — to a survivor of the Armenian genocide, to ancestors shaped by violence and displacement, and the hidden patterns shared by others living with chronic illness. Filming Italy Sardinia 2025 on day